Validating Chemical Probes

What are chemical probes and why are they important? Chemical probes are designed to selectively address a biological question; this is distinctly different from a drug, which is designed to produce a clinical outcome! Simple guidelines can be used to generate high-quality chemical probes and obtain reliable data to further our understanding of human biology and disease.

Please cite the EFMC Best Practices in Medicinal Chemistry WG work as following (please include both):

1. J. Quancard, B. Cox, D. Finsinger, S. M. Guéret, I. V. Hartung, H. F. Koolman, J. Messinger, G. Sbardella, S. Laufer, ChemMedChem 2020, 15, 2388. https://doi.org/10.1002/cmdc.202000597;
2. The material (webinars, slide decks and case studies) is freely accessible for personal use or for use in further training or teaching material from the EFMC website https://www.efmc.info/validating-chemical-probes